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1.

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.

Weinstock, Joshua S; Gopakumar, Jayakrishnan; Burugula, Bala Bharathi; Uddin, Md Mesbah; Jahn, Nikolaus; Belk, Julia A; Bouzid, Hind; Daniel, Bence; Miao, Zhuang; Ly, Nghi; Mack, Taralynn M; Luna, Sofia E; Prothro, Katherine P; Mitchell, Shaneice R; Laurie, Cecelia A; Broome, Jai G; Taylor, Kent D; Guo, Xiuqing; Sinner, Moritz F; von Falkenhausen, Aenne S; Kääb, Stefan; Shuldiner, Alan R; O'Connell, Jeffrey R; Lewis, Joshua P; Boerwinkle, Eric; Barnes, Kathleen C; Chami, Nathalie; Kenny, Eimear E; Loos, Ruth J F; Fornage, Myriam; Hou, Lifang; Lloyd-Jones, Donald M; Redline, Susan; Cade, Brian E; Psaty, Bruce M; Bis, Joshua C; Brody, Jennifer A; Silverman, Edwin K; Yun, Jeong H; Qiao, Dandi; Palmer, Nicholette D; Freedman, Barry I; Bowden, Donald W; Cho, Michael H; DeMeo, Dawn L; Vasan, Ramachandran S; Yanek, Lisa R; Becker, Lewis C; Kardia, Sharon L R; Peyser, Patricia A.

Nature ; 616(7958): 755-763, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-37046083

2.

Genetic diversity fuels gene discovery for tobacco and alcohol use.

Saunders, Gretchen R B; Wang, Xingyan; Chen, Fang; Jang, Seon-Kyeong; Liu, Mengzhen; Wang, Chen; Gao, Shuang; Jiang, Yu; Khunsriraksakul, Chachrit; Otto, Jacqueline M; Addison, Clifton; Akiyama, Masato; Albert, Christine M; Aliev, Fazil; Alonso, Alvaro; Arnett, Donna K; Ashley-Koch, Allison E; Ashrani, Aneel A; Barnes, Kathleen C; Barr, R Graham; Bartz, Traci M; Becker, Diane M; Bielak, Lawrence F; Benjamin, Emelia J; Bis, Joshua C; Bjornsdottir, Gyda; Blangero, John; Bleecker, Eugene R; Boardman, Jason D; Boerwinkle, Eric; Boomsma, Dorret I; Boorgula, Meher Preethi; Bowden, Donald W; Brody, Jennifer A; Cade, Brian E; Chasman, Daniel I; Chavan, Sameer; Chen, Yii-Der Ida; Chen, Zhengming; Cheng, Iona; Cho, Michael H; Choquet, Hélène; Cole, John W; Cornelis, Marilyn C; Cucca, Francesco; Curran, Joanne E; de Andrade, Mariza; Dick, Danielle M; Docherty, Anna R; Duggirala, Ravindranath.

Nature ; 612(7941): 720-724, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36477530

3.

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Taliun, Daniel; Harris, Daniel N; Kessler, Michael D; Carlson, Jedidiah; Szpiech, Zachary A; Torres, Raul; Taliun, Sarah A Gagliano; Corvelo, André; Gogarten, Stephanie M; Kang, Hyun Min; Pitsillides, Achilleas N; LeFaive, Jonathon; Lee, Seung-Been; Tian, Xiaowen; Browning, Brian L; Das, Sayantan; Emde, Anne-Katrin; Clarke, Wayne E; Loesch, Douglas P; Shetty, Amol C; Blackwell, Thomas W; Smith, Albert V; Wong, Quenna; Liu, Xiaoming; Conomos, Matthew P; Bobo, Dean M; Aguet, François; Albert, Christine; Alonso, Alvaro; Ardlie, Kristin G; Arking, Dan E; Aslibekyan, Stella; Auer, Paul L; Barnard, John; Barr, R Graham; Barwick, Lucas; Becker, Lewis C; Beer, Rebecca L; Benjamin, Emelia J; Bielak, Lawrence F; Blangero, John; Boehnke, Michael; Bowden, Donald W; Brody, Jennifer A; Burchard, Esteban G; Cade, Brian E; Casella, James F; Chalazan, Brandon; Chasman, Daniel I; Chen, Yii-Der Ida.

Nature ; 590(7845): 290-299, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33568819

4.

Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.

Wang, Yuxuan; Selvaraj, Margaret Sunitha; Li, Xihao; Li, Zilin; Holdcraft, Jacob A; Arnett, Donna K; Bis, Joshua C; Blangero, John; Boerwinkle, Eric; Bowden, Donald W; Cade, Brian E; Carlson, Jenna C; Carson, April P; Chen, Yii-Der Ida; Curran, Joanne E; de Vries, Paul S; Dutcher, Susan K; Ellinor, Patrick T; Floyd, James S; Fornage, Myriam; Freedman, Barry I; Gabriel, Stacey; Germer, Soren; Gibbs, Richard A; Guo, Xiuqing; He, Jiang; Heard-Costa, Nancy; Hildalgo, Bertha; Hou, Lifang; Irvin, Marguerite R; Joehanes, Roby; Kaplan, Robert C; Kardia, Sharon Lr; Kelly, Tanika N; Kim, Ryan; Kooperberg, Charles; Kral, Brian G; Levy, Daniel; Li, Changwei; Liu, Chunyu; Lloyd-Jone, Don; Loos, Ruth Jf; Mahaney, Michael C; Martin, Lisa W; Mathias, Rasika A; Minster, Ryan L; Mitchell, Braxton D; Montasser, May E; Morrison, Alanna C; Murabito, Joanne M.

Am J Hum Genet ; 110(10): 1704-1717, 2023 10 05.

Artículo en Inglés | MEDLINE | ID: mdl-37802043

5.

Identification of type 2 diabetes loci in 433,540 East Asian individuals.

Spracklen, Cassandra N; Horikoshi, Momoko; Kim, Young Jin; Lin, Kuang; Bragg, Fiona; Moon, Sanghoon; Suzuki, Ken; Tam, Claudia H T; Tabara, Yasuharu; Kwak, Soo-Heon; Takeuchi, Fumihiko; Long, Jirong; Lim, Victor J Y; Chai, Jin-Fang; Chen, Chien-Hsiun; Nakatochi, Masahiro; Yao, Jie; Choi, Hyeok Sun; Iyengar, Apoorva K; Perrin, Hannah J; Brotman, Sarah M; van de Bunt, Martijn; Gloyn, Anna L; Below, Jennifer E; Boehnke, Michael; Bowden, Donald W; Chambers, John C; Mahajan, Anubha; McCarthy, Mark I; Ng, Maggie C Y; Petty, Lauren E; Zhang, Weihua; Morris, Andrew P; Adair, Linda S; Akiyama, Masato; Bian, Zheng; Chan, Juliana C N; Chang, Li-Ching; Chee, Miao-Li; Chen, Yii-Der Ida; Chen, Yuan-Tsong; Chen, Zhengming; Chuang, Lee-Ming; Du, Shufa; Gordon-Larsen, Penny; Gross, Myron; Guo, Xiuqing; Guo, Yu; Han, Sohee; Howard, Annie-Green.

Nature ; 582(7811): 240-245, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32499647

6.

Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.

Hindy, George; Dornbos, Peter; Chaffin, Mark D; Liu, Dajiang J; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C; Bielak, Lawrence F; Bis, Joshua C; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L; Bottinger, Erwin; Bowden, Donald W; Bown, Matthew J; Brody, Jennifer A; Broome, Jai G; Burtt, Noël P; Cade, Brian E; Centeno-Cruz, Federico; Chan, Edmund; Chang, Yi-Cheng; Chen, Yii-Der I; Cheng, Ching-Yu; Choi, Won Jung; Chowdhury, Rajiv; Contreras-Cubas, Cecilia; Córdova, Emilio J; Correa, Adolfo; Cupples, L Adrienne; Curran, Joanne E; Danesh, John; de Vries, Paul S; DeFronzo, Ralph A; Doddapaneni, Harsha; Duggirala, Ravindranath; Dutcher, Susan K; Ellinor, Patrick T; Emery, Leslie S.

Am J Hum Genet ; 109(1): 81-96, 2022 01 06.

Artículo en Inglés | MEDLINE | ID: mdl-34932938

7.

A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.

Li, Zilin; Li, Xihao; Zhou, Hufeng; Gaynor, Sheila M; Selvaraj, Margaret Sunitha; Arapoglou, Theodore; Quick, Corbin; Liu, Yaowu; Chen, Han; Sun, Ryan; Dey, Rounak; Arnett, Donna K; Auer, Paul L; Bielak, Lawrence F; Bis, Joshua C; Blackwell, Thomas W; Blangero, John; Boerwinkle, Eric; Bowden, Donald W; Brody, Jennifer A; Cade, Brian E; Conomos, Matthew P; Correa, Adolfo; Cupples, L Adrienne; Curran, Joanne E; de Vries, Paul S; Duggirala, Ravindranath; Franceschini, Nora; Freedman, Barry I; Göring, Harald H H; Guo, Xiuqing; Kalyani, Rita R; Kooperberg, Charles; Kral, Brian G; Lange, Leslie A; Lin, Bridget M; Manichaikul, Ani; Manning, Alisa K; Martin, Lisa W; Mathias, Rasika A; Meigs, James B; Mitchell, Braxton D; Montasser, May E; Morrison, Alanna C; Naseri, Take; O'Connell, Jeffrey R; Palmer, Nicholette D; Peyser, Patricia A; Psaty, Bruce M; Raffield, Laura M.

Nat Methods ; 19(12): 1599-1611, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36303018

8.

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.

Graff, Mariaelisa; Justice, Anne E; Young, Kristin L; Marouli, Eirini; Zhang, Xinruo; Fine, Rebecca S; Lim, Elise; Buchanan, Victoria; Rand, Kristin; Feitosa, Mary F; Wojczynski, Mary K; Yanek, Lisa R; Shao, Yaming; Rohde, Rebecca; Adeyemo, Adebowale A; Aldrich, Melinda C; Allison, Matthew A; Ambrosone, Christine B; Ambs, Stefan; Amos, Christopher; Arnett, Donna K; Atwood, Larry; Bandera, Elisa V; Bartz, Traci; Becker, Diane M; Berndt, Sonja I; Bernstein, Leslie; Bielak, Lawrence F; Blot, William J; Bottinger, Erwin P; Bowden, Donald W; Bradfield, Jonathan P; Brody, Jennifer A; Broeckel, Ulrich; Burke, Gregory; Cade, Brian E; Cai, Qiuyin; Caporaso, Neil; Carlson, Chris; Carpten, John; Casey, Graham; Chanock, Stephen J; Chen, Guanjie; Chen, Minhui; Chen, Yii-Der I; Chen, Wei-Min; Chesi, Alessandra; Chiang, Charleston W K; Chu, Lisa; Coetzee, Gerry A.

Am J Hum Genet ; 108(4): 564-582, 2021 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-33713608

9.

Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.

Palmer, Nicholette D; Kahali, Bratati; Kuppa, Annapurna; Chen, Yanhua; Du, Xiaomeng; Feitosa, Mary F; Bielak, Lawrence F; O'Connell, Jeffrey R; Musani, Solomon K; Guo, Xiuqing; Smith, Albert V; Ryan, Kathleen A; Eirksdottir, Gudny; Allison, Matthew A; Bowden, Donald W; Budoff, Matthew J; Carr, J Jeffrey; Chen, Yii-Der I; Taylor, Kent D; Correa, Adolfo; Crudup, Breland F; Halligan, Brian; Yang, Jian; Kardia, Sharon L R; Launer, Lenore J; Fu, Yi-Ping; Mosley, Thomas H; Norris, Jill M; Terry, James G; O'Donnell, Christopher J; Rotter, Jerome I; Wagenknecht, Lynne E; Gudnason, Vilmundur; Province, Michael A; Peyser, Patricia A; Speliotes, Elizabeth K.

Hum Mol Genet ; 30(15): 1443-1456, 2021 07 09.

Artículo en Inglés | MEDLINE | ID: mdl-33856023

10.

Metabolomic profiling of glucose homeostasis in African Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS).

Okut, Hayrettin; Lu, Yingchang; Palmer, Nicholette D; Chen, Yii-Der Ida; Taylor, Kent D; Norris, Jill M; Lorenzo, Carlos; Rotter, Jerome I; Langefeld, Carl D; Wagenknecht, Lynne E; Bowden, Donald W; Ng, Maggie C Y.

Metabolomics ; 19(4): 35, 2023 04 02.

Artículo en Inglés | MEDLINE | ID: mdl-37005925

11.

Methods for estimating insulin resistance from untargeted metabolomics data.

Hsu, Fang-Chi; Palmer, Nicholette D; Chen, Shyh-Huei; Ng, Maggie C Y; Goodarzi, Mark O; Rotter, Jerome I; Wagenknecht, Lynne E; Bancks, Michael P; Bergman, Richard N; Bowden, Donald W.

Metabolomics ; 19(8): 72, 2023 08 09.

Artículo en Inglés | MEDLINE | ID: mdl-37558891

12.

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Kraja, Aldi T; Liu, Chunyu; Fetterman, Jessica L; Graff, Mariaelisa; Have, Christian Theil; Gu, Charles; Yanek, Lisa R; Feitosa, Mary F; Arking, Dan E; Chasman, Daniel I; Young, Kristin; Ligthart, Symen; Hill, W David; Weiss, Stefan; Luan, Jian'an; Giulianini, Franco; Li-Gao, Ruifang; Hartwig, Fernando P; Lin, Shiow J; Wang, Lihua; Richardson, Tom G; Yao, Jie; Fernandez, Eliana P; Ghanbari, Mohsen; Wojczynski, Mary K; Lee, Wen-Jane; Argos, Maria; Armasu, Sebastian M; Barve, Ruteja A; Ryan, Kathleen A; An, Ping; Baranski, Thomas J; Bielinski, Suzette J; Bowden, Donald W; Broeckel, Ulrich; Christensen, Kaare; Chu, Audrey Y; Corley, Janie; Cox, Simon R; Uitterlinden, Andre G; Rivadeneira, Fernando; Cropp, Cheryl D; Daw, E Warwick; van Heemst, Diana; de Las Fuentes, Lisa; Gao, He; Tzoulaki, Ioanna; Ahluwalia, Tarunveer S; de Mutsert, Renée; Emery, Leslie S.

Am J Hum Genet ; 104(1): 112-138, 2019 01 03.

Artículo en Inglés | MEDLINE | ID: mdl-30595373

13.

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

Kowalski, Madeline H; Qian, Huijun; Hou, Ziyi; Rosen, Jonathan D; Tapia, Amanda L; Shan, Yue; Jain, Deepti; Argos, Maria; Arnett, Donna K; Avery, Christy; Barnes, Kathleen C; Becker, Lewis C; Bien, Stephanie A; Bis, Joshua C; Blangero, John; Boerwinkle, Eric; Bowden, Donald W; Buyske, Steve; Cai, Jianwen; Cho, Michael H; Choi, Seung Hoan; Choquet, Hélène; Cupples, L Adrienne; Cushman, Mary; Daya, Michelle; de Vries, Paul S; Ellinor, Patrick T; Faraday, Nauder; Fornage, Myriam; Gabriel, Stacey; Ganesh, Santhi K; Graff, Misa; Gupta, Namrata; He, Jiang; Heckbert, Susan R; Hidalgo, Bertha; Hodonsky, Chani J; Irvin, Marguerite R; Johnson, Andrew D; Jorgenson, Eric; Kaplan, Robert; Kardia, Sharon L R; Kelly, Tanika N; Kooperberg, Charles; Lasky-Su, Jessica A; Loos, Ruth J F; Lubitz, Steven A; Mathias, Rasika A; McHugh, Caitlin P; Montgomery, Courtney.

PLoS Genet ; 15(12): e1008500, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31869403

14.

Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans.

Guan, Meijian; Keaton, Jacob M; Dimitrov, Latchezar; Hicks, Pamela J; Xu, Jianzhao; Palmer, Nicholette D; Ma, Lijun; Das, Swapan K; Chen, Yii-Der I; Coresh, Josef; Fornage, Myriam; Franceschini, Nora; Kramer, Holly; Langefeld, Carl D; Mychaleckyj, Josyf C; Parekh, Rulan S; Post, Wendy S; Rasmussen-Torvik, Laura J; Rich, Stephen S; Rotter, Jerome I; Sedor, John R; Thornley-Brown, Denyse; Tin, Adrienne; Wilson, James G; Freedman, Barry I; Bowden, Donald W; Ng, Maggie C Y.

Hum Genomics ; 13(1): 21, 2019 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-31092297

15.

Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European Americans and African Americans with Type 2 Diabetes Mellitus.

Brown, Landon K; Xu, Jianzhao; Freedman, Barry I; Hsu, Fang-Chi; Bowden, Donald W; Koch, Kenneth L.

Dig Dis Sci ; 65(8): 2321-2330, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-31820181

16.

QRS duration is associated with all-cause mortality in type 2 diabetes: The diabetes heart study.

Singleton, Matthew J; German, Charles; Hari, Krupal J; Saylor, Georgia; Herrington, David M; Soliman, Elsayed Z; Freedman, Barry I; Bowden, Donald W; Bhave, Prashant D; Yeboah, Joseph.

J Electrocardiol ; 58: 150-154, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-31895990

17.

Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus.

Liu, Mingxia; Frej, Cecilia; Langefeld, Carl D; Divers, Jasmin; Bowden, Donald W; Carr, J Jeffrey; Gebre, Abraham K; Xu, Jianzhao; Larsson, Benny; Dahlbäck, Björn; Freedman, Barry I; Parks, John S.

J Lipid Res ; 60(8): 1425-1431, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31133557

18.

Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.

Keaton, Jacob M; Gao, Chuan; Guan, Meijian; Hellwege, Jacklyn N; Palmer, Nicholette D; Pankow, James S; Fornage, Myriam; Wilson, James G; Correa, Adolfo; Rasmussen-Torvik, Laura J; Rotter, Jerome I; Chen, Yii-Der I; Taylor, Kent D; Rich, Stephen S; Wagenknecht, Lynne E; Freedman, Barry I; Ng, Maggie C Y; Bowden, Donald W.

Genet Epidemiol ; 42(6): 559-570, 2018 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-29691896

19.

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Liu, Ching-Ti; Raghavan, Sridharan; Maruthur, Nisa; Kabagambe, Edmond Kato; Hong, Jaeyoung; Ng, Maggie C Y; Hivert, Marie-France; Lu, Yingchang; An, Ping; Bentley, Amy R; Drolet, Anne M; Gaulton, Kyle J; Guo, Xiuqing; Armstrong, Loren L; Irvin, Marguerite R; Li, Man; Lipovich, Leonard; Rybin, Denis V; Taylor, Kent D; Agyemang, Charles; Palmer, Nicholette D; Cade, Brian E; Chen, Wei-Min; Dauriz, Marco; Delaney, Joseph A C; Edwards, Todd L; Evans, Daniel S; Evans, Michele K; Lange, Leslie A; Leong, Aaron; Liu, Jingmin; Liu, Yongmei; Nayak, Uma; Patel, Sanjay R; Porneala, Bianca C; Rasmussen-Torvik, Laura J; Snijder, Marieke B; Stallings, Sarah C; Tanaka, Toshiko; Yanek, Lisa R; Zhao, Wei; Becker, Diane M; Bielak, Lawrence F; Biggs, Mary L; Bottinger, Erwin P; Bowden, Donald W; Chen, Guanjie; Correa, Adolfo; Couper, David J; Crawford, Dana C.

Am J Hum Genet ; 99(1): 56-75, 2016 Jul 07.

Artículo en Inglés | MEDLINE | ID: mdl-27321945

20.

Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.

Taylor, Kent D; Guo, Xiuqing; Zangwill, Linda M; Liebmann, Jeffrey M; Girkin, Christopher A; Feldman, Robert M; Dubiner, Harvey; Hai, Yang; Samuels, Brian C; Panarelli, Joseph F; Mitchell, John P; Al-Aswad, Lama A; Park, Sung Chul; Tello, Celso; Cotliar, Jeremy; Bansal, Rajendra; Sidoti, Paul A; Cioffi, George A; Blumberg, Dana; Ritch, Robert; Bell, Nicholas P; Blieden, Lauren S; Davis, Garvin; Medeiros, Felipe A; Das, Swapan K; Divers, Jasmin; Langefeld, Carl D; Palmer, Nicholette D; Freedman, Barry I; Bowden, Donald W; Ng, Maggie C Y; Ida Chen, Yii-Der; Ayyagari, Radha; Rotter, Jerome I; Weinreb, Robert N.

Ophthalmology ; 126(1): 38-48, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30352225

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